Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus.

Liu Q, Tang Z, Surdenikova L, et al. Cell, 2009; 139: 1353-65.

Read more

Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis.

Kim BS, Miyagawa F, Cho YH, Bennett CL, Clausen BE, Katz SI, Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol. 2009:…

Read more

Cellular basis of itch sensation.

Sun YG*, Zhao ZQ*, Meng XL, Yin J, Liu XY, and Chen ZF. (2009) Cellular Basis of Itch Sensation. Science  325(5947): 1531-1534. (*equal contribution)   PMID: 19661382

Read more

The c-kit signaling pathway is involved in the development of persistent pain.

Sun YG, Gracias NG, Drobish JK, Vasko MR, Gereau RW, and Chen ZF. (2009) The c-kit signaling pathway is involved in the development of persistent pain. Pain 144(1-2):178-186.  PMID:…

Read more

Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients.

Council, M.L., Gardner, J.M., Helms, C., Liu, Y., Cornelius, L.A., Bowcock, A.M.  Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients. Exp Dermatol. 2009;18(5):485-7.

Read more

Stimulation of Mucosal Secretion by Lubiprostone (SPI-0211) in Guinea Pig Small Intestine and Colon.

Fei G, Wang YZ, Liu S, Hu H, Wang GD, Qu MH, Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD (2009). Stimulation of Mucosal Secretion by…

Read more

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.

Jørgensen HF, Terry A, Beretta C, Pereira CF, Leleu M, Chen ZF, Kelly C, Merkenschlager M, and Fisher AG. (2009) REST selectively represses a subset of RE1-containing neuronal genes…

Read more

Zinc activates damage-sensing TRPA1 ion channels.

Hu H*, Bandell M*, Petrus M, Zhu MX, Patapoutian A (2009). Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5(3): 183-190. PMID: 19202543.

Read more

Is REST required for ESC pluripotency.

Jørgensen HF, Chen ZF, Merkenschlager M, and Fisher AG. (2009) Is REST required for ESC pluripotency. Nature 457(7233): E4-E5.  PMID: 19242417

Read more

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.

Hu H*, Grandl J*, Bandell M, Petrus M, and Patapoutian A (2009). Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci…

Read more

Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration.

Zheng, H.  Gao, L. Feng, Y. Yuan, L. Zhao, H. Cornelius, L.A. Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration. Cancer Res 2009; 69:…

Read more