Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.

Kim S*, Barry DM*, Liu XY*, Yin S, Munanairi A, Meng QT, Cheng W, Mo P, Wan L, Liu SB, Ratnayake K, Zhao ZQ, Gautam N, Zheng J,Karunarathne WK, Chen ZF.Sci Signal. 2016 Jul 19;9(437) PMID: 27436359. (*These authors contributed equally to this work.)

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Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus.

Xu AZ, Tripathi SV, Kau AL, Schaffer A, Kim BS. Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus. J Am Acad Dermatol. 2016 May;74(5):1017-20. PMID: 27085236

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New insights into basophil heterogeneity.

Oetjen LK, Noti M, Kim BS. New insights into basophil heterogeneity. Semin Immunopathol. 2016 May 13. [Epub ahead of print] PMID: 27178409

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Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord.

Barry DM, Li H, Liu XY, Shen KF, Liu XT, Wu ZY, Munanairi A, Chen XJ, Yin J, Sun YG, Li YQ, Chen ZF. Mol Pain. 2016 Apr 11;12. pii: 1744806916643724. doi: 10.1177/1744806916643724. Print 2016 Feb.

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Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.

Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18. PMID: 26756551

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Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons.

Gu QD, Moss CR 2nd, Kettelhut KL, Gilbert CA, Hu H. Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Front Physiol. 2016 Feb 29;7:65. PMID: 26973533

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A histamine-independent itch pathway is required for allergic ocular itch.

Huang CC, Kim YS, Olson WP, Li F, Guo C, Luo W, Huang AJ, Liu Q. A histamine-independent itch pathway is required for allergic ocular itch. J Allergy Clin Immunol.…

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Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M,Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y. Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction. Cell Rep. 2016 Jun 28;16(1):106-19. PMID: 27320922

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Pirt contributes to uterine contraction-induced pain in mice.

Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, Jian T, Yang N, Shi H, Tang M, He Q, Lan L, Liu Q, Guan Y, Dong X,…

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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF.Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. 2015 Aug 21;349(6250):873-6. PMID: 26293964  

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The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane.

Kimball C, Luo J, Yin S, Hu H, Dhaka A (2015). The pore Loop domain of TRPV1 is required for its activation by the volatile anesthetics chloroform and isoflurane. Mol…

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Molecular and cellular mechanisms that initiate pain and itch.

Luo J, Feng J, Liu S, Walters ET, Hu H (2015). Molecular and cellular mechanisms that initiates pain and itch. Cell and Mol Life Sci 72(17):3201-23. PMID: 25894692

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Identification and characterization of two ankyrin-B isoforms in mammalian heart.

Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR (2015). Identification and characterization of two ankyrin-B isoforms in mammalian heart. Cardiovasc Res [Epub ahead of…

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Kv Channel S1-S2 Linker Working as a Binding Site of Human β-Defensin 2 for Channel Activation Modulation.

Feng J, Yang W, Xie Z, Xiang F, Cao Z, Li W, Hu H, Chen Z, Wu Y (2015). Kv channel S1-S2 linker working as a binding site of human…

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Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice.

Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q. Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology.…

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Low Filaggrin Monomer Repeats in African American Pediatric Patients With Moderate to Severe Atopic Dermatitis.

Quiggle AM, Goodwin ZA, Marfatia TR, Kumar MG, Ciliberto H, Bayliss SJ, de Guzman Strong C. (2015) Low filaggrin monomer repeats in African-American pediatric patients with moderate to severe atopic dermatitis.…

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The role of the Mrgpr receptor family in itch.

Liu Q, Dong X. The role of the Mrgpr receptor family in itch. Handb Exp Pharmacol. 2015;226:71-88. doi: 10.1007/978-3-662-44605-8_5. Review. PubMed PMID: 25861775

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Group 2 Innate Lymphoid Cells in Health and Disease.

Kim BS, Artis D. Group 2 Innate Lymphoid Cells in Health and Disease. Cold Spring Harb Perspect Biol. 2015 Jan 8;7(5). PMID: 25573713.

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Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.

Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL (2014). Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends upon subunit composition. Mol Pharmacol 86(6): 760-772. PMID:…

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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015; 519(7542):242-6. PMID: 25533952. 

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Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells.

Yin S, Hu Q, Luo J, Li Y, Lu C, Chen X and Hu H (2014). Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine…

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Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling.

Zhao ZQ, Liu XY, Jeffry J, Karunarathne WKA, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L, Wu ZY, Kim S, Huo FQ, Mo P, Barry DM,…

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Thermally activated TRPV3 channels

Luo J, Hu H (2014). Thermally activated TRPV3 channels. Curr Top Membr 74: 325-364. PMID: 25366242

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Innate Lymphoid Cells in the Skin.

Kim BS. Innate Lymphoid Cells in the Skin. J Invest Dermatol. 2015; 135(3):673-678.

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Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of…

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Cross-Inhibition of NMBR and GRPR Signaling Maintains Normal Histaminergic Itch Transmission.

Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE, Li YQ, Chen ZF. J Neurosci. 2014 Sep 10;34(37):12402-14. 

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Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin.

Kim BS, Wang K, Siracusa MC, Saenz SA, Brestoff JR, Monticelli LA, Noti M, Tait Wojno ED, Fung TC, Kubo M, Artis D. Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin. J…

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.

Matkovich SJ, Edwards JR, Grossenheider  TC, de Guzman Strong C, DornII GW (2014) Epigenetic coordination of embryonic heart transcription by dynamically regulated lncRNAs. Proc. Natl. Acad. Sci. 111(33): 12264-9. PMID:25071214

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Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice.

Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, et al. Pain. 2014;155(8):1613-21.

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Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem.

Kim JY, Kim A, Zhao ZQ, Liu XY, Chen ZF. Mol Brain. 2014;7(1):48.

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Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis.

Noti M, Kim BS, Siracusa MC, Rak GD, Kubo M, Moghaddam AE, Sattentau QA, Comeau MR, Spergel JM, Artis D, Exposure to food allergens through inflamed skin promotes intestinal food…

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LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.

Yin S, Luo J, Qian A, Yu W, and Hu H (2014). LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.  Br J Pharmacol 171:…

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Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate.

Liu Z, Zhou J, Li Y, Hu F, Lu Y, Ma M, Feng Q, Zhang JE, Wang D, Zeng J, Bao J, Kim JY, Chen ZF, El Mestikawy S, Luo M. Neuron. 2014; 81(6):1360-74.

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Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis.

Margolis DJ, Kim B, Apter AJ, Gupta J, Hoffstad O, Papadopoulos M, Mitra N, Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis, JAMA Dermatol. 2014:150(3):254-9. PMID: 24401911

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MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain.

He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R,…

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Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development.

Oh, I.Y., Albea, D.M., Goodwin, Z.A., Quiggle, A.M., Baker, B.P., Guggisberg, A.M., Kroner, G.M., de Guzman Strong, C. (2014) Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex…

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B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway

Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ and Chen ZF. Mol Pain. 2014; 10:4

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CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients.

Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH, CD164 and FCRL3 are highly expressed…

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Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.

Luo J, Walters ET, Carlton SM and Hu H (2013). Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol 11(6):652-63 (invited review). PMID: 24396340

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TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation.

Siracusa MC, Saenz SA, Wojno ED, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR,…

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Chronic itch development in sensory neurons requires BRAF signaling pathways

Zhao ZQ*, Huo FQ*, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey,…

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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.

Yin S*, Luo J*, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, and Hu H (2013). Retinoids activate the irritant…

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IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.

Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D, IL-25 simultaneously elicits distinct populations of innate lymphoid…

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Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C,…

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Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune activation compared to extrinsic AD

Suarez-Farinas, M., Dhingra, D., Gittler, J, Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J.G., Guttman-Yassky, E.  (2013) Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune…

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Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.

Roediger G, Kyle R, Yip KH, Sumaria N, Guy TV, Kim BS, Mitchell MJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, Fazekas…

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Over-Expression of the Gastrin-Releasing Peptide in Cutaneous Nerve Fibers and its Receptor in Spinal Cord in Primates with Chronic Itch.

Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G. J Invest Dermatol. 2013 Oct;133(10):2489-92

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Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.

Dalal, J.  Roh, J.H., Maloney, S.E., Akuffo, A., Shah, S., Yuan, H., Wamsley, B., Jones, W.B., de Guzman Strong, C., Holtzman, D., Heintz, N., Dougherty, J.D.  (2013) Translational profiling of…

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A subpopulation of nociceptors specifically linked to itch

Han L, Ma C, Liu Q, et al. Nature Neuroscience. 2013;16(2):174-82.  

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Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

Efendiev R*, Bavencoffe A*, Hu H, Zhu MX, Dessauer CW (2013). Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel. J Biol Chem 288(6): 3929-3937.  PMID: 23264624

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TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.

Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Van Voorhees AS, Smith DE, Comeau MR, Artis D, TSLP elicits IL-33-independent innate lymphoid cell responses to promote…

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Mechanisms of itch evoked by beta-alanine.

Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte R, and Dong X. The Journal of Neuroscience. 2012; 32(42):14532-7. 

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Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes.

Luo J, Stewart R, Berdeaux R, and Hu H (2012). Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes. J Invest Dermatol 132(9): 2158-2165. PMID: 22622423      

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Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis.

Gittler, J.K., Shemer, A., Suarez-Farinas, M., Fuentes-Duculan, J., Gulewicz, K.J., Wang, C.Q.F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J.G., Guttman-Yassky, E.  (2012) Progressive Activation of Th2/Th22 characterizes…

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CaMKII is Essential for the Function of the Enteric Nervous System.

Gao N*, Luo J*, Uray K, Wang G, Wang X, Xia Y, Wood JD, and Hu H (2012). CaMKII is Essential for the Function of the Enteric Nervous System. PLoS…

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TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.

Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, et al. Journal of Clinical Investigation. 2012; 122(6):2195-207. 

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Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.

Hill DA, Siracusa MC, Abt MA, Kim BS, Kobuley D, Kubo M, Kambayashi T, LaRosa DF, Renner ED, Orange JS, Bushman FD, Artis D, Commensal bacteria-derived signals regulate basophil hematopoiesis…

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Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway.

Huang V, Hepper D, Anadkat M, Cornelius LA. Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway.  Arch Dermatol 2012; 148:628-633

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Preparing the next generation in academic medicine: recruiting and retaining the best.

de Guzman Strong, C. and Cornelius, L.A.  (2012) Preparing the next generation in academic medicine: recruiting and retaining the best.  Journal of Investigative Dermatology, 132(3 Pt2):1018-25.  PMID: 22330268.

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The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex.

Xiang CX, Zhang KH, Johnson R.L., Jacquin M.F. and Chen ZF. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal…

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Unidirectional cross activation of GRPR by MOR1D uncouples itch and analgesia-induced by opioids.

Liu XY, Liu ZC, Sun YG, Ross M, Kim SI, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, and Chen ZF. (2011) Unidirectional cross activation of GRPR by…

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Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3

Luo J, Zhu Y, Zhu MX, & Hu H (2011). Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3. J Vis Exp.  (54).…

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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.

Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF,…

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Itch Signaling in the nervous system.

Jeffry J, Kim SI, and Chen ZF. (2011) Itch Signaling in the nervous system. Physiology  26(4):286-292. PMID: 21841076

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The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.

Liu Q*, Weng HJ*, Patel KN*, Tang Z, Bai H, and Dong X. Science Signaling 2011; 4(181):ra45 *Denotes equal contribution (Cover article).

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Cancer and Itch.

Chiang HC, Huang V, Cornelius LA.  Cancer and Itch.  In: Semin in Cutan Med and Surg.  Editors: Arndt KA, LeBoit PE and Wintroub BU., Elsevier, 2011, 30:107-112

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Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.

Patel KN, Liu Q, Meeker S, Undem BJ, Dong X. PLoS ONE. 2011; 6(5):e20559.

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TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.

Wilson SR, Gerhold KA, Bifolck FA, Liu Q, Patel K, Dong X, Bautista DM. Nature Neuroscience, 2011; 14:595-602

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Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.

Liu Y, Jiang Y-A, Si YX, Kim JY, Chen ZF, and Rao Y. (2011) Molecular regulation of sexual preference revealed by  genetic studies of 5-HT in the brains of…

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VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Ölund C, Simith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, and Kullander K. (2010) VGLUT2-Dependent…

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Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

Guan Y*, Liu Q*, Tang Z, Raja SN, Anderson DJ, Dong X. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2010; 107: 15933-8 *Denotes…

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The transcription factor, Lmx1b, is necessary for development of the principal trigeminal nucleus-based lemniscal pathway.

Xiang CX, Zhang K-H, Yin J, Arends JA, Erzurumlu RS, Jacquin MF, and Chen ZF. (2010) The transcription factor, Lmx1b, is necessary for development of the principal trigeminal nucleus-based…

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A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis

de Guzman Strong, C., Conlan, S., Deming, C.B., Cheng, J, Sears, K.E., Segre, J.A. (2010) A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for…

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Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.

Hu H*, Tian J*, Zhu Y*, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX (2010). Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459(4): 579-592. 

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Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus.

Liu Q, Tang Z, Surdenikova L, et al. Cell, 2009; 139: 1353-65.

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Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis.

Kim BS, Miyagawa F, Cho YH, Bennett CL, Clausen BE, Katz SI, Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol. 2009:…

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Cellular basis of itch sensation.

Sun YG*, Zhao ZQ*, Meng XL, Yin J, Liu XY, and Chen ZF. (2009) Cellular Basis of Itch Sensation. Science  325(5947): 1531-1534. (*equal contribution)   PMID: 19661382

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The c-kit signaling pathway is involved in the development of persistent pain.

Sun YG, Gracias NG, Drobish JK, Vasko MR, Gereau RW, and Chen ZF. (2009) The c-kit signaling pathway is involved in the development of persistent pain. Pain 144(1-2):178-186.  PMID:…

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Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients.

Council, M.L., Gardner, J.M., Helms, C., Liu, Y., Cornelius, L.A., Bowcock, A.M.  Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients. Exp Dermatol. 2009;18(5):485-7.

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Stimulation of Mucosal Secretion by Lubiprostone (SPI-0211) in Guinea Pig Small Intestine and Colon.

Fei G, Wang YZ, Liu S, Hu H, Wang GD, Qu MH, Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD (2009). Stimulation of Mucosal Secretion by…

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REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.

Jørgensen HF, Terry A, Beretta C, Pereira CF, Leleu M, Chen ZF, Kelly C, Merkenschlager M, and Fisher AG. (2009) REST selectively represses a subset of RE1-containing neuronal genes…

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Zinc activates damage-sensing TRPA1 ion channels.

Hu H*, Bandell M*, Petrus M, Zhu MX, Patapoutian A (2009). Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5(3): 183-190. PMID: 19202543.

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Is REST required for ESC pluripotency.

Jørgensen HF, Chen ZF, Merkenschlager M, and Fisher AG. (2009) Is REST required for ESC pluripotency. Nature 457(7233): E4-E5.  PMID: 19242417

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Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.

Hu H*, Grandl J*, Bandell M, Petrus M, and Patapoutian A (2009). Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci…

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Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration.

Zheng, H.  Gao, L. Feng, Y. Yuan, L. Zhao, H. Cornelius, L.A. Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration. Cancer Res 2009; 69:…

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Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system.

Liu S, Qu MH, Ren W, Hu H, Gao N, Wang GD, Wang XY, Fei G, Zuo F, Xia Y, Wood JD (2008) Differential expression of canonical (classical) transient receptor…

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Rest-Mediated regulation of extracellular matrix is crucial for neural development.

Sun Y-M, Cooper M, Finch S, Lin H-H, Chen ZF, Williams BP, and Buckley NJ. (2008) Rest-Mediated regulation of extracellular matrix is crucial for neural development. PLoS ONE 3(11):…

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Pore region of TRPV3 ion channel is specifically required for heat activation.

Grandl J*, Hu H*, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A (2008). Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci 11(9): 1007-1013.…

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Involvement of P311 in the affective, but not in the sensory component of pain.

Sun YG*, Gao YJ*, Zhao ZQ, Huang B, Yin J, Taylor GA, and Chen ZF. (2008) Involvement of P311 in the affective, but not in the sensory component of…

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Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.

Kim AY, Tang Z, Liu Q, et al.  Cell 2008; 133: 475-85.

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In Drg11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning.

Jacquin MF, Joop JA. Xiang C, Shapiro LA, Ribak CE, and Chen ZF. (2008)  In Drg11 knock-out mice, trigeminal cell death is extensive and does not account for failed…

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Navigating the genome

de Guzman Strong, C. and Segre, J.A.  (2008) Navigating the genome.  Journal of Cell Science 121 (Pt 7):921-3.  PMID: 18354081.

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Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.

Hodges MR, Tattersall, GJ, Harris MB, McEvoy S, Richerson DN, Deneris ES, Johnson RL, Chen ZF, and Richerson GB. (2008) Defects in breathing and thermoregulation in mice with near-complete…

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Agonists of the Mas Related Gene (Mrgs) orphan receptors as Novel Mediators of Mast Cell-Sensory Nerve Interactions.

Lee MG, Dong X, Liu Q, Patel KN, Choi OH, Vonakis B, Undem BJ. Journal of Immunology 2008; 180: 2251-2255.

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Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system.

Fang X, Liu S, Wang XY, Gao N, Hu H, Wang GD, Cook CH, Needleman BJ, Mikami DJ, Xia Y, Fei GJ, Hicks GA, Wood JD (2008). Neurogastroenterology of tegaserod…

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Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.

Zhao ZQ, Gao YJ, Sun YG, Zhao CS, Gereau RW., and Chen ZF. (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or…

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Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

 Liu Q, Vrontou S, Rice FL, et al. Nature Neuroscience 2007; 10: 946-8.

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Gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.

Sun YG, and Chen ZF. (2007) Gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448(7154): 700-703. PMID: 17653196

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Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11.

Wang CZ, Shi M, Yang LL, Yang RQ,Luo ZG, Jacquin MF, Chen ZF, and Ding YQ. (2007) Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor,…

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Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine.

Wang GD, Wang XY, Hu H, Liu S, Gao N, Fang X, Xia Y, Wood JD (2007). Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small…

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