The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice.

Feng J, Luo J, Mack MR, Yang P, Zhang F, Wang G, Gong X, Cai T, Mei Z, Kim BS, Yin S, Hu H. The antimicrobial peptide human beta-defensin 2…

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Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M,Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y. Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction. Cell Rep. 2016 Jun 28;16(1):106-19. PMID: 27320922

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Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.

Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18. PMID: 26756551

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Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons.

Gu QD, Moss CR 2nd, Kettelhut KL, Gilbert CA, Hu H. Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Front Physiol. 2016 Feb 29;7:65. PMID: 26973533

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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF.Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. 2015 Aug 21;349(6250):873-6. PMID: 26293964  

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The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane.

Kimball C, Luo J, Yin S, Hu H, Dhaka A (2015). The pore Loop domain of TRPV1 is required for its activation by the volatile anesthetics chloroform and isoflurane. Mol…

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Molecular and cellular mechanisms that initiate pain and itch.

Luo J, Feng J, Liu S, Walters ET, Hu H (2015). Molecular and cellular mechanisms that initiates pain and itch. Cell and Mol Life Sci 72(17):3201-23. PMID: 25894692

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Identification and characterization of two ankyrin-B isoforms in mammalian heart.

Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR (2015). Identification and characterization of two ankyrin-B isoforms in mammalian heart. Cardiovasc Res [Epub ahead of…

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Kv Channel S1-S2 Linker Working as a Binding Site of Human β-Defensin 2 for Channel Activation Modulation.

Feng J, Yang W, Xie Z, Xiang F, Cao Z, Li W, Hu H, Chen Z, Wu Y (2015). Kv channel S1-S2 linker working as a binding site of human…

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Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.

Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL (2014). Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends upon subunit composition. Mol Pharmacol 86(6): 760-772. PMID:…

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Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells.

Yin S, Hu Q, Luo J, Li Y, Lu C, Chen X and Hu H (2014). Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine…

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Thermally activated TRPV3 channels

Luo J, Hu H (2014). Thermally activated TRPV3 channels. Curr Top Membr 74: 325-364. PMID: 25366242

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LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.

Yin S, Luo J, Qian A, Yu W, and Hu H (2014). LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.  Br J Pharmacol 171:…

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Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.

Luo J, Walters ET, Carlton SM and Hu H (2013). Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol 11(6):652-63 (invited review). PMID: 24396340

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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.

Yin S*, Luo J*, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, and Hu H (2013). Retinoids activate the irritant…

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Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

Efendiev R*, Bavencoffe A*, Hu H, Zhu MX, Dessauer CW (2013). Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel. J Biol Chem 288(6): 3929-3937.  PMID: 23264624

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Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes.

Luo J, Stewart R, Berdeaux R, and Hu H (2012). Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes. J Invest Dermatol 132(9): 2158-2165. PMID: 22622423      

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CaMKII is Essential for the Function of the Enteric Nervous System.

Gao N*, Luo J*, Uray K, Wang G, Wang X, Xia Y, Wood JD, and Hu H (2012). CaMKII is Essential for the Function of the Enteric Nervous System. PLoS…

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Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3

Luo J, Zhu Y, Zhu MX, & Hu H (2011). Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3. J Vis Exp.  (54).…

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Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.

Hu H*, Tian J*, Zhu Y*, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX (2010). Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459(4): 579-592. 

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Stimulation of Mucosal Secretion by Lubiprostone (SPI-0211) in Guinea Pig Small Intestine and Colon.

Fei G, Wang YZ, Liu S, Hu H, Wang GD, Qu MH, Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD (2009). Stimulation of Mucosal Secretion by…

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Zinc activates damage-sensing TRPA1 ion channels.

Hu H*, Bandell M*, Petrus M, Zhu MX, Patapoutian A (2009). Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5(3): 183-190. PMID: 19202543.

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Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.

Hu H*, Grandl J*, Bandell M, Petrus M, and Patapoutian A (2009). Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci…

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Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system.

Liu S, Qu MH, Ren W, Hu H, Gao N, Wang GD, Wang XY, Fei G, Zuo F, Xia Y, Wood JD (2008) Differential expression of canonical (classical) transient receptor…

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Pore region of TRPV3 ion channel is specifically required for heat activation.

Grandl J*, Hu H*, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A (2008). Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci 11(9): 1007-1013.…

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Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system.

Fang X, Liu S, Wang XY, Gao N, Hu H, Wang GD, Cook CH, Needleman BJ, Mikami DJ, Xia Y, Fei GJ, Hicks GA, Wood JD (2008). Neurogastroenterology of tegaserod…

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Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine.

Wang GD, Wang XY, Hu H, Liu S, Gao N, Fang X, Xia Y, Wood JD (2007). Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small…

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Caenorhabditis elegans TRPA-1 functions in mechanosensation.

Kindt KS*, Viswanath V*, Macpherson L, Quast K, Hu H, Patapoutian A, Schafer WR (2007). Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci 10(5): 568-577. PMID: 17450139 

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Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.

Gao N, Hu H, Liu S, Gao C, Xia Y, Wood JD (2007). Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small…

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Platelet-activating factor in the enteric nervous system of the guinea pig small intestine.

Wang GD, Wang XY, Hu H, Fang XC, Liu S, Gao N, Xia Y (2006) Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. Am J…

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Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.

Ni D, Gu Q, Hu H, Gao N, Zhu MX, Lee LY (2006). Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. Am J…

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Potentiation of TRPV3 channel function by unsaturated fatty acids.

Hu H*, Xiao R*, Wang C*, Gao N, Colton CK, Wood JD, Zhu MX. (2006) Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol 208(1): 201-212. PMID: 16557504

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Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine.

Fang X, Hu H, Gao N, Liu S, Wang GD, Wang XY, Xia Y, Wood JD (2006). Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine. Eur…

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The P2Y purinergic receptor expressed by enteric neurones in guinea-pig intestine.

Gao N, Hu H, Zhu MX, Fang X, Liu S, Gao C, Wood JD (2006). The P2Y purinergic receptor expressed by enteric neurones in guinea-pig intestine. Neurogastroenterol Motil 18(4): 316-323. PMID:…

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Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.

Liu S, Gao N, Hu H, Wang X, Wang GD, Fang X, Gao X, Xia Y, Wood JD (2006). Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea…

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Angiotensin receptors and actions in guinea pig enteric nervous system.

Wang GD, Wang XY, Hu H, Fang XC, Liu S, Gao N, Xia Y, Wood JD (2005). Angiotensin receptors and actions in guinea pig enteric nervous system. Am J Physiol…

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2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.

Gu Q, Lin RL, Hu H, Zhu MX, Lee LY (2005). 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol…

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Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system.

Liu S, Gao X, Gao N, Wang X, Fang X, Hu H, Wang GD, Xia Y, Wood JD (2005). Expression of type 1 corticotropin-releasing factor receptor in the guinea pig…

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The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system.

Tseng PH, Lin HP, Hu H, Wang C, Zhu MX, Chen CS (2004). The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate -sensitive calcium entry system. Biochemistry…

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An alternative splicing product of the murine trpv1 gene dominant-negatively modulates the activity of TRPV1 channels.

Wang C*, Hu H*, Colton C, Wood JD, Zhu MX (2004).An alternative splicing product of the murine trpv1 gene dominant-negatively modulates the activity of TRPV1 channels. J Biol Chem 279(36):…

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2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.

Hu H*, Gu Q*, Wang C*, Colton C, Tang J, Kinoshita-Kawada M, Lee YL, Wood JD, Zhu MX (2004). 2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.…

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Metabotropic signal transduction for bradykinin in submucosal neurons of guinea-pig small intestine.

Hu H, Gao N, Liu S, Ren J, Xia Y, Wood JD (2004). Metabotropic signal transduction for bradykinin in submucosal neurons of guinea-pig small intestine. J Pharmacol Exp Ther 309:…

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Action of bradykinin in the submucosal plexus of guinea pig small intestine.

Hu H, Gao N, Liu S, Ren J, Xia Y, Wood JD (2004). Action of bradykinin in the submucosal plexus of guinea-pig small intestine. J Pharmacol Exp Ther 309: 320-327.…

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Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system.

Hu H, Gao N, Zhu MX, Liu S, Ren J, Gao C, Xia Y, Wood JD (2003). Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system. J Physiol (London) 550(Pt 2): 493-504. PMID: 12807993

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Actions of galanin on neurotransmission in the submucous plexus of guinea pig small intestine.

Liu S, Hu H, Gao C, Gao N, Xia Y, Wood JD (2003). Actions of galanin on neurotransmission in the submucous plexus of guinea pig small intestine. Eur J Pharmacol…

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Actions of bradykinin on electrical and synaptic behavior of neurones in the myenteric plexus of guinea-pig small intestine.

Hu H, Liu S, Gao N, Xia Y, Mostafa R, Ren J, Zafirov DH, Wood JD (2003). Actions of bradykinin on electrical and synaptic behavior of neurones in the myenteric…

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Neuroimmune interactions in Guinea-Pig stomach and small intestine.

Liu S, Hu, H, Gao N, Gao C, Wang G, Wang X, Gao X, Xia Y, Wood JD (2003). Neuroimmune interactions in Guinea-Pig stomach and small intestine. Am J Physiol…

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Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Liu S, Hu H, Gao C, Gao N, Wang G, Wang X, Gao X, Xia Y, Wood JD (2003). Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig…

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Effects of stimulating protease-activated receptors on myenteric neurons in guinea-pig small intestine.

Gao C, Liu S, Hu H, Gao N, Xia Y, Wood JD (2002). Effects of stimulating protease-activated receptors on myenteric neurons in guinea-pig small intestine.  Gastroenterology 123:1554-1564. PMID: 12404230

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Neurofilament 145-immunoreactive neurons in the enteric nervous system of guinea pig ilem.

Hu H, Gao N, Lin Z, Gao C, Liu S, Ren J, Xia Y and Wood JD (2002). Neurofilament 145-immunoreactive neurons in the enteric nervous system of guinea pig ilem.…

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Immunoreactivity of Hu proteins facilitates identification of myenteric neurones in guinea-pig small intestine.

Lin Z, Gao N, Hu H, Liu S, Gao C, Kim G, Ren J, Xia Y, Peck OC, Wood JD (2002). Immunoreactivity of Hu proteins facilitates identification of myenteric neurones…

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P2X(7) receptors in the enteric nervous system of guinea-pig small intestine.

Hu H, Gao N, Lin Z, Gao C, Liu S, Ren J, Xia Y and Wood JD (2001). P2X(7) receptors in the enteric nervous system of guinea-pig small intestine. J Comp…

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Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.

Liu S, Hu H, Gao C, Gao N, Ren J, Xia Y, Wood JD (2001). Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.…

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Galanin suppresses calcium conductance and activates inwardly rectifying potassium channels in myenteric neurons from guinea-pig small intestine.

Ren J, Hu H, Starob A. & Wood JD (2001). Galanin suppresses calcium conductance and activates inwardly rectifying potassium channels in myenteric neurons from guinea-pig small intestine. Neurogastroenterol Motil 13(3):…

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Glutamate receptors in the enteric nervous system: ionotropic or metabotropic?

Ren J, Hu H, Liu S, Xia Y & Wood JD (2000). Glutamate receptors in the enteric nervous system: ionotropic or metabotropic? Neurogastroenterol & Motil 12(3): 257-264. PMID: 10867623

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Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the submucosal plexus of guinea-pig small intestine.

Liu S, Xia Y, Hu H, Ren J, Gao C, Wood JD (2000). Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the submucosal plexus of guinea-pig small intestine. Eur…

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Clostridium Difficile Toxin A excites enteric neurons and suppresses sympathetic neurotransmission in the guinea pig.

Xia Y, Hu H, Liu S, Pothoulakis C and Wood, JD (2000). Clostridium Difficile Toxin A excites enteric neurons and suppresses sympathetic neurotransmission in the guinea pig. Gut 46: 481-486. PMID:…

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Functional group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum.

Hu H, Ren J, Liu S, Gao C, Xia Y & Wood JD (1999). Functional group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum. Br J Pharmacol (special…

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Glutamate modulates synaptic transmission in the submucosal plexus of guinea pig small intestine.

Ren J, Hu H, Liu S, Xia Y & Wood JD (1999). Glutamate modulates synaptic transmission in the submucosal plexus of guinea pig small intestine. Neuroreport 10(14): 3045-3048. PMID: 10549820

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IL-1 and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea-pig enteric nervous system.

Xia Y, Hu H, Liu S, Ren J, Zafirov, DH & Wood JD (1999). IL-1 and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea-pig enteric nervous system.…

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Enhancement of GABA-activated current by muscarine in rat dorsal root ganglion neurons.

Hu H, Shao M & Li ZW (1999). Enhancement of GABA-activated current by muscarine in rat dorsal root ganglion neurons. Neuroscience 89(3): 883-890. PMID: 10199621

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Inhibitory effect of baclofen on GABA-induced depolarization and GABA-activated current in rat primary sensory neurons.

Si JQ, Li ZW, Hu H, Zhou XP and Guan BC (1997). Inhibitory effect of baclofen on GABA-induced depolarization and GABA-activated current in rat primary sensory neurons. Neuroscience 81(3): 821-827. PMID:…

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Modulation of nicotinic ACh-, GABAA- and 5-HT3-receptor functions by external H-7, a protein kinase inhibitor, in rat sensory neurones.

Hu H and Li ZW (1997). Modulation of nicotinic ACh-, GABAA-, 5-HT3-receptor functions by external H-7, a protein kinase inhibitor, in rat sensory neurons. Br J Pharmacol 122(6): 1195-1201. PMID: 9401786

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Modulation by adenosine of GABA-activated current in rat dorsal root ganglion neurons.

Hu H and Li ZW (1997). Modulation by adenosine of GABA-activated current in rat dorsal root ganglion neurons. J Physiol (London) 510 ( Pt 1): 67-75. PMID: 9174995

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Evidence for the existence of substance P autoreceptor in the membrane of rat dorsal root ganglion neurons.

Hu H, Li ZW & Si JQ (1997). Evidence for the existence of substance P autoreceptor in the membrane of rat dorsal root ganglion neurons. Neuroscience 77(2): 535-541. PMID: 9472409

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