Over-Expression of the Gastrin-Releasing Peptide in Cutaneous Nerve Fibers and its Receptor in Spinal Cord in Primates with Chronic Itch.
Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G.
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The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex.
Xiang CX, Zhang KH, Johnson R.L., Jacquin M.F. and Chen ZF. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal…
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Unidirectional cross activation of GRPR by MOR1D uncouples itch and analgesia-induced by opioids.
Liu XY, Liu ZC, Sun YG, Ross M, Kim SI, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, and Chen ZF. (2011) Unidirectional cross activation of GRPR…
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Itch Signaling in the nervous system.
Jeffry J, Kim SI, and Chen ZF. (2011) Itch Signaling in the nervous system. Physiology 26(4):286-292. PMID: 21841076
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Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.
Liu Y, Jiang Y-A, Si YX, Kim JY, Chen ZF, and Rao Y. (2011) Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of…
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VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Ölund C, Simith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, and Kullander K. (2010) VGLUT2-Dependent…
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The transcription factor, Lmx1b, is necessary for development of the principal trigeminal nucleus-based lemniscal pathway.
Xiang CX, Zhang K-H, Yin J, Arends JA, Erzurumlu RS, Jacquin MF, and Chen ZF. (2010) The transcription factor, Lmx1b, is necessary for development of the principal trigeminal nucleus-based…
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Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong…
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Cellular basis of itch sensation.
Sun YG*, Zhao ZQ*, Meng XL, Yin J, Liu XY, and Chen ZF. (2009) Cellular Basis of Itch Sensation. Science 325(5947): 1531-1534. (*equal contribution) PMID: 19661382
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The c-kit signaling pathway is involved in the development of persistent pain.
Sun YG, Gracias NG, Drobish JK, Vasko MR, Gereau RW, and Chen ZF. (2009) The c-kit signaling pathway is involved in the development of persistent pain. Pain 144(1-2):178-186. PMID:…
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REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.
Jørgensen HF, Terry A, Beretta C, Pereira CF, Leleu M, Chen ZF, Kelly C, Merkenschlager M, and Fisher AG. (2009) REST selectively represses a subset of RE1-containing neuronal genes…
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Is REST required for ESC pluripotency.
Jørgensen HF, Chen ZF, Merkenschlager M, and Fisher AG. (2009) Is REST required for ESC pluripotency. Nature 457(7233): E4-E5. PMID: 19242417
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Rest-Mediated regulation of extracellular matrix is crucial for neural development.
Sun Y-M, Cooper M, Finch S, Lin H-H, Chen ZF, Williams BP, and Buckley NJ. (2008) Rest-Mediated regulation of extracellular matrix is crucial for neural development. PLoS ONE 3(11):…
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Involvement of P311 in the affective, but not in the sensory component of pain.
Sun YG*, Gao YJ*, Zhao ZQ, Huang B, Yin J, Taylor GA, and Chen ZF. (2008) Involvement of P311 in the affective, but not in the sensory component of…
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In Drg11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning.
Jacquin MF, Joop JA. Xiang C, Shapiro LA, Ribak CE, and Chen ZF. (2008) In Drg11 knock-out mice, trigeminal cell death is extensive and does not account for failed…
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Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.
Hodges MR, Tattersall, GJ, Harris MB, McEvoy S, Richerson DN, Deneris ES, Johnson RL, Chen ZF, and Richerson GB. (2008) Defects in breathing and thermoregulation in mice with near-complete…
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Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.
Zhao ZQ, Gao YJ, Sun YG, Zhao CS, Gereau RW., and Chen ZF. (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or…
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Gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.
Sun YG, and Chen ZF. (2007) Gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448(7154): 700-703. PMID: 17653196
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Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11.
Wang CZ, Shi M, Yang LL, Yang RQ,Luo ZG, Jacquin MF, Chen ZF, and Ding YQ. (2007) Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor,…
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Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs.
Zhao ZQ, Chiechio S, Sun YG, Zhang KH, Zhao CS, Scott M, Johnson R., Deneris E., Renner K., Gereau RW., and Chen ZF.(2007) Mice lacking central serotonergic neurons show…
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Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.
Guo C, Qiu HY, Huang Y, Chen HX, Yang RQ, Chen SD, Johnson R.L., Chen ZF, and Ding YQ. (2007) Lmx1b is essential for Fgf8 and Wnt1 expression in…
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Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity.
Zhao ZQ, Scott M., Chiechio S, Wang JS, Renner K, Gereau RW., Johnson R., Deneris E., and Chen ZF. (2006) Lmx1b is required for maintenance of central serotonergic neurons…
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Involvement of DRG11 in the development of the primary afferent nociceptive system.
Rebelo S, Chen ZF, Anderson DJ, and Lima D. (2006) Involvement of DRG11 in the development of the primary afferent nociceptive system Mol. Cell. Neurosci. 33(3): 236-246. PMID: 16978876
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Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.
Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams R.P., and Chen ZF. (2006) Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral…
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Molecular determinants of the face map development in the trigeminal brainstem.
Erzurumlu RS, Chen ZF, and Jacquin MF. (2006) Molecular determinants of the face map development in the trigeminal brainstem. Anat Rec. 288(2): 121-134. PMID: 16432893
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Transcriptional control of the serotonergic neuronal development.
Chen ZF and Ding YQ. Transcriptional control of the serotonergic neuronal development.(2006) In "Transcription factors in nervous system" Thiel G (Ed.), Wiley-VCH , Weinheim, pp. 143-156.
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Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.
Wu LJ, Toyoda H, Zhao MG, Lee YS, Rang J, KO SW, Jia YH, Shum FWF, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson…
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Generation and characterization of the PKCγ-Cre mouse line.
Ding YQ, Xiang CX, and Chen ZF. (2005) Generation and characterization of the PKCγ-Cre mouse line. Genesis 43(1): 28-33. PMID: 16106361
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Ventral migration of early-born neurons requires DCC and is essential for the projections of primary afferents in the spinal cord.
Ding YQ, Kim JY, Xu YS, Rao Y, and Chen ZF. (2005) Ventral migration of early-born neurons requires DCC and is essential for the projections of primary afferents in…
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A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression.
Dunston JA, Reimschisel T, Ding YQ, Sweeney E, Johnson RL, Chen ZF, and McIntosh I. (2005) A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of…
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Focal adhesion kinase in netrin-1 signaling.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, and Xiong WC. (2004) Focal…
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Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.
Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, and Chen ZF. (2004) Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal…
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Lmx1b is essential for the development of serotonergic neurons.
Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson Johan, Deneris E, Johnson RL, and Chen ZF. (2003) Lmx1b is essential for the development of serotonergic neurons. Nat.…
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Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.
Ding YQ, Yin J, Xu HM, Jacquin MF, and Chen ZF. (2003) Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. J. Neurosci.…
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Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases.
Wei F, Qiu C, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, and Zhuo M. (2002) Genetic elimination of behavioral sensitization…
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1,25-dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system.
Li YC, Kong J, Wei M, Chen ZF, Liu SQ, and Cao LP. (2002) 1,25-dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J. Clin Invest. 110(2):…
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The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord.
Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, and Anderson DJ. (2001) The paired homeodomain protein DRG11 is required for the…
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Point mutant mice with hypersensitive [alpha ] 4 nicotinic receptors show dopaminergic deficits and increased anxiety.
Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen ZF, Bowers BJ, Boulter…
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Genetic enhancement of inflammatory pain by forebrain NR2B overexpression.
Wei F, Wang GD, Kerchner GA, Kim SJ, Xu HM, Chen ZF, and Zhuo M. (2001) Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat. Neurosci. 4(2): 164-169.…
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Genetic ablation of parathyroid glands by targeted mutation of Glial cells missing2 reveals an auxiliary source of parathyroid hormone secretion.
Gunther T*, Chen ZF*, Kim J, Priemel M, Rueger JM, Amling M, Moseley JM, Martin TJ, Anderson DJ, and Karsenty G. (2000) Genetic ablation of parathyroid glands by targeted…
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Symmetrical mutant phenotype of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.
Gerety SS, Wang HU, Chen ZF, and Anderson DJ. (1999) Symmetrical mutant phenotype of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell 4(3):…
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NRSF/REST is required in vivo for repression of multiple neuronal target genes in both neural and non-neuronal tissues during embryogenesis.
Chen ZF, Paquette AJ, and Anderson DJ. (1998) NRSF/REST is required in vivo for repression of multiple neuronal target genes in both neural and non-neuronal tissues during embryogenesis. Nat.…
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Isolation and characterization of mammalian homologs of the Drosophila gene, glial cells missing.
Kim J, Jones BW, Zock C, Chen ZF, Wang H, Goodman CS, and Anderson DJ. (1998) Isolation and characterization of mammalian homologs of the Drosophila gene, glial cells missing.…
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Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.
Wang HU, Chen ZF, and Anderson DJ. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93(5): 741-753. PMID:…
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Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.
Ma QF, Chen ZF, Barrantes IB, Pompa J, and Anderson DJ. (1998) Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20(3): 469-482.…
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Twist is required in head mesenchyme for cranial neural tube morphogenesis.
Chen ZF, and Behringer RR. (1995) Twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 9(6): 686-699. PMID: 7729687
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