Dr. Brian Kim is Assistant Professor of Dermatology, Anesthesiology, Pathology and Immunology, and Co-Director of the Center for the Study of Itch at Washington University School of Medicine in St. Louis. His laboratory focuses on innate immune mechanisms that underlie skin inflammation and the sensation of itch. Specifically, the Kim Lab identified previously unrecognized contributions of group 2 innate lymphoid cells (ILC2s) and basophils to the pathogenesis of atopic dermatitis (AD) in both mice and humans. These cells have emerged as critical sources of the type 2 cytokines IL-4, IL-5, and IL-13, which are now among the most important targets for biologic therapy in AD and other allergic disorders. More recently, the Kim Lab was the first to identify functionality of IL-4 receptor alpha (IL-4R) and Janus kinases (JAKs) in sensory neurons as master regulators of chronic itch in AD and other disorders. These studies have immediate clinical implications as type 2 cytokine and JAK blockade have emerged as some of the most efficacious therapeutics in AD. His research on the immune regulation of AD and itch has led to awards and funding from the National Institutes of Health, Doris Duke Charitable Foundation, American Skin Association, American Academy of Dermatology, and the American Society for Clinical Investigation.
Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch.
Feng J, Luo J, Yang P, Du J, Kim BS, Hu H. Science. 2018 May 4;360(6388):530-533. PMID: 29724954.
Sensory TRP channels contribute differentially to skin inflammation and persistent itch.
Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017 Oct 30;8(1):980. PMID: 29081531. PMCID: PMC5661746.
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.
Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Cell. 2017…
Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus.
Xu AZ, Tripathi SV, Kau AL, Schaffer A, Kim BS. Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus. J Am Acad Dermatol. 2016 May;74(5):1017-20. PMID: 27085236
New insights into basophil heterogeneity.
Oetjen LK, Noti M, Kim BS. New insights into basophil heterogeneity. Semin Immunopathol. 2016 May 13. [Epub ahead of print] PMID: 27178409
Group 2 Innate Lymphoid Cells in Health and Disease.
Kim BS, Artis D. Group 2 Innate Lymphoid Cells in Health and Disease. Cold Spring Harb Perspect Biol. 2015 Jan 8;7(5). PMID: 25573713.
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015; 519(7542):242-6. PMID: 25533952.
Innate Lymphoid Cells in the Skin.
Kim BS. Innate Lymphoid Cells in the Skin. J Invest Dermatol. 2015; 135(3):673-678.
Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin.
Kim BS, Wang K, Siracusa MC, Saenz SA, Brestoff JR, Monticelli LA, Noti M, Tait Wojno ED, Fung TC, Kubo M, Artis D. Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin. J…
Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis.
Noti M, Kim BS, Siracusa MC, Rak GD, Kubo M, Moghaddam AE, Sattentau QA, Comeau MR, Spergel JM, Artis D, Exposure to food allergens through inflamed skin promotes intestinal food…
Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis.
Margolis DJ, Kim B, Apter AJ, Gupta J, Hoffstad O, Papadopoulos M, Mitra N, Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis, JAMA Dermatol. 2014:150(3):254-9. PMID: 24401911
CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients.
Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH, CD164 and FCRL3 are highly expressed…
TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation.
Siracusa MC, Saenz SA, Wojno ED, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR,…
IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.
Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D, IL-25 simultaneously elicits distinct populations of innate lymphoid…
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.
Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C,…
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Roediger G, Kyle R, Yip KH, Sumaria N, Guy TV, Kim BS, Mitchell MJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, Fazekas…
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.
Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Van Voorhees AS, Smith DE, Comeau MR, Artis D, TSLP elicits IL-33-independent innate lymphoid cell responses to promote…
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.
Hill DA, Siracusa MC, Abt MA, Kim BS, Kobuley D, Kubo M, Kambayashi T, LaRosa DF, Renner ED, Orange JS, Bushman FD, Artis D, Commensal bacteria-derived signals regulate basophil hematopoiesis…
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF,…
Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis.
Kim BS, Miyagawa F, Cho YH, Bennett CL, Clausen BE, Katz SI, Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol. 2009:…
Potential new therapy relieves chronic itch
Congratulations to Dr. Brian Kim's team!
Dr. Brian Kim, dermatologist, and Landon Oetjen, MD/PhD student, of the CSI discover highly promising new pathway for the treatment of chronic itch. Please read news Record, Daily Mail.
CBS news: Finding new ways to combat chronic itch
BBC interview: Itchy and Scratchy
"What is an itch and how does scratching stop it? Why does scratching some itches feel so good?!" asks Xander Tarver from Wisborough Green in West Sussex.
Our doctors set off to probe the mysteries of itch, and discover that this overlooked area of medicine is revealing surprising results about the human brain. From why itching is contagious to why scratching is pleasurable, we get under the skin of this medical mystery.
The programme features interview with dermatologist Dr Brian Kim from…
Brian Kim Discusses Itch on Great Day St. Louis
What's the Itch? Dr. Brian Kim explains some reasons why you can't get rid of the itch. Watch video here.
Brian Kim named the recipient of 2016 Clinical Scientist Development Award by DDCF, Congratulations!
Dr. Brian Kim won the prestigious 2016 Clinical Scientist Development Award, according to The Doris Duke Charitable Foundation's announcement. He is one of the 17 exceptional physician scientists selected from 169 applicants by a panel of experts in medical experts. Congratulations to Dr. Brian Kim! Please read DDCF award announcement here.