Strong

Cristina de Guzman Strong, PhD

Assistant Professor of Dermatology


  Email Cristina de Guzman Strong, PhD


Biography

Dr. de Guzman Strong is an assistant professor in the Division of Dermatology located in the Department of Internal Medicine at Washington University School of Medicine.  As a core member of the Center for the Study of Itch, she is also a member of the Center for Pharmacogenomics.  Dr. de Guzman Strong received her Ph.D. at the University of Alabama at Birmingham and further pursued her post-doctoral training under Dr. Julie Segre at the National Human Genome Research Institute.  She has an established track record applying genomics approaches towards understanding skin barrier formation. Cristina is currently investigating the epigenetic and transcriptional regulation of the Epidermal Differentiation Complex (EDC), a required chromosomal locus for barrier formation, in development and disease.  Additionally, she is one of the four prestigious Faculty Diversity Scholars at WUSM.  Her interest in itch is a natural extension of her expertise in the genomics of skin barrier function and atopic dermatitis.


Low Filaggrin Monomer Repeats in African American Pediatric Patients With Moderate to Severe Atopic Dermatitis.

Quiggle AM, Goodwin ZA, Marfatia TR, Kumar MG, Ciliberto H, Bayliss SJ, de Guzman Strong C. (2015) Low filaggrin monomer repeats in African-American pediatric patients with moderate to severe atopic dermatitis.…

Read more

Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.

Matkovich SJ, Edwards JR, Grossenheider  TC, de Guzman Strong C, DornII GW (2014) Epigenetic coordination of embryonic heart transcription by dynamically regulated lncRNAs. Proc. Natl. Acad. Sci. 111(33): 12264-9. PMID:25071214

Read more

Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development.

Oh, I.Y., Albea, D.M., Goodwin, Z.A., Quiggle, A.M., Baker, B.P., Guggisberg, A.M., Kroner, G.M., de Guzman Strong, C. (2014) Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex…

Read more

Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune activation compared to extrinsic AD

Suarez-Farinas, M., Dhingra, D., Gittler, J, Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J.G., Guttman-Yassky, E.  (2013) Intrinsic atopic dermatitis (AD) shows similar Th2 and higher Th17 immune…

Read more

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.

Dalal, J.  Roh, J.H., Maloney, S.E., Akuffo, A., Shah, S., Yuan, H., Wamsley, B., Jones, W.B., de Guzman Strong, C., Holtzman, D., Heintz, N., Dougherty, J.D.  (2013) Translational profiling of…

Read more

Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis.

Gittler, J.K., Shemer, A., Suarez-Farinas, M., Fuentes-Duculan, J., Gulewicz, K.J., Wang, C.Q.F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J.G., Guttman-Yassky, E.  (2012) Progressive Activation of Th2/Th22 characterizes…

Read more

Preparing the next generation in academic medicine: recruiting and retaining the best.

de Guzman Strong, C. and Cornelius, L.A.  (2012) Preparing the next generation in academic medicine: recruiting and retaining the best.  Journal of Investigative Dermatology, 132(3 Pt2):1018-25.  PMID: 22330268.

Read more

A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis

de Guzman Strong, C., Conlan, S., Deming, C.B., Cheng, J, Sears, K.E., Segre, J.A. (2010) A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for…

Read more

Navigating the genome

de Guzman Strong, C. and Segre, J.A.  (2008) Navigating the genome.  Journal of Cell Science 121 (Pt 7):921-3.  PMID: 18354081.

Read more

Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.

de Guzman Strong, C., Wertz, P., Wang, C., Yang, F., Meltzer, P.S., Andl, T., Millar S.E., Ho, I-C., Pai, S-Y., Segre, J.A. (2006) Lipid defect underlies selective skin barrier…

Read more

The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells.

Kim, H-G., de Guzman, C.G., Swindle, C.S., Cotta, C.V., Gartland, L., Scott, E., Klug, C.A. (2004) The ETS-family transcription factor, PU.1, is necessary for the maintenance of fetal liver…

Read more

Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage.

Zhang, Z., Cotta, C.V., Stephan, R.P., de Guzman, C.G., Klug, C.A. (2003) Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage. EMBO J.…

Read more

The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo.

de Guzman, C. G., Johnson, A., and Klug, C. A. (2003) The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell…

Read more

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation.

de Guzman, C.G., Warren, A.W., Zhang, Z., Gartland, L., Erickson, P., Drabkin, H., Hiebert, S., Klug, C.A. (2002) Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a…

Read more

Ligand-binding properties of recombinant human IRBP

Nickerson, J.M., Mody, V., de Guzman, C.G., Heron, K.A., Marciante, K., Boatright, J., Si, J.S., Lin, Z.Y. (1995) Ligand-binding properties of recombinant human IRBP. Degenerative Diseases of the Retina, Plenum…

Read more

Zane Goodwin has been selected to attend NSF’s 2015 Data Science Workshop at UW

Zane Goodwin has been selected to attend NSF’s 2015 Data Science Workshop at UW in August for his white paper on compositional and phylogenetic methods for the identification of antibiotic resistance genes.

Read more


Mary Mathyer joins the lab!

Mary Mathyer joins the lab!

Read more


Zane Goodwin wins a Society of Investigative Dermatology Albert Kligman travel fellowship award to attend SID!

Zane Goodwin wins a Society of Investigative Dermatology Albert Kligman travel fellowship award to attend SID!

Read more


Zane Goodwin joins the lab on March 15, 2012.

Zane Goodwin joins the lab on March 15, 2012.

Read more


Jessica Geahlen joins the lab on October 15, 2012.

 Jessica Geahlen joins the lab on October 15, 2012.

Read more