Cornelius

Lynn Cornelius, MBBS

Winfred and Emma Showman Professor of Dermatology

Chief, Division of Dermatology


  Email Lynn Cornelius, MBBS


Biography

Dr. Cornelius has had extensive experience in leading clinical and research initiatives as the Division Chief of Dermatology at WUSM, and as both a clinical investigator and a practicing dermatologist.  Dr. Cornelius has served as Chief of Dermatology since 2000.  She also serves as Co-Director of the CSI.

Under her leadership, the Dermatology Division has experienced extensive growth, in both the clinical practice, and most recently, in research. Within the institution, she has served a leadership role in the Melanoma Multidisciplinary Clinic, where clinicians and investigators focus on melanoma clinical practice and clinical investigation.  She has established and maintains the melanoma tissue and biobank that employs a web-based portal system linking melanoma patient clinical information with human tissue specimens. She serves as a Principal Investigator, and sub-investigator on several investigator-initiated and industry-sponsored clinical trials in melanoma.  This strong leadership background has her well poised to direct the development of collaborative investigations in Itch.

Dr. Cornelius plans to recruit a physician-scientist, trained in dermatology, and build a similar scientifically-focused multidisciplinary practice for the treatment of chronic itch patients as part of the newly established CSI at Washington University.  This new initiative will provide excellent synergies with our pediatric dermatologists, who have busy clinical practices treating patients with atopic dermatitis. In addition, as a practicing dermatologist, she routinely sees patients with chronic itch   – those currently in her cutaneous oncology (melanoma and cutaneous T cell lymphoma) and general dermatology practice (AD, psoriasis) as well as patients with chronic itch of undetermined etiology. Through her efforts in melanoma, she has extensive experience utilizing the ICTS Tissue Procurement Core, and data entry into web-based, HIPPA compliant clinical study and tissue portals – ClinPortal and CaTissue. Over 300 melanoma patients have been consented, DNA banked and clinical and tissue information linked and entered into these databases.


Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway.

Huang V, Hepper D, Anadkat M, Cornelius LA. Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway.  Arch Dermatol 2012; 148:628-633

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Cancer and Itch.

Chiang HC, Huang V, Cornelius LA.  Cancer and Itch.  In: Semin in Cutan Med and Surg.  Editors: Arndt KA, LeBoit PE and Wintroub BU., Elsevier, 2011, 30:107-112

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Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients.

Council, M.L., Gardner, J.M., Helms, C., Liu, Y., Cornelius, L.A., Bowcock, A.M.  Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients. Exp Dermatol. 2009;18(5):485-7.

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Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration.

Zheng, H.  Gao, L. Feng, Y. Yuan, L. Zhao, H. Cornelius, L.A. Downregulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival and migration. Cancer Res 2009; 69:…

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Ras-Associated Protein-1 Regulates Extracellular Signal-Regulated Kinase Activation and Migration in Melanoma Cells: Two Processes Important to Melanoma Tumorigenesis and Metastasis.

Gao L, Feng Y, Bowers R, Becker-Hapak MB, Gardner J, Council L, Linette G, Zhao H, and Cornelius LA. Ras-Associated Protein-1 Regulates Extracellular Signal-Regulated Kinase Activation and Migration in…

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New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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Cornelius named Showman Professor

Lynn A. Cornelius, MD, chief of the Division of Dermatology at Washington University School of Medicine in St. Louis, has been named the Winfred A. and Emma R. Showman Professor in Dermatology.

Cornelius’ appointment was announced by Larry Shapiro, MD, executive vice chancellor for medical affairs and dean of the medical school.

“Lynn is exceptional in her field and a real standout at the School of Medicine,” Shapiro says. “She is beloved by her patients and well respected by her…

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Center for the Study of Itch opens

Washington University School of Medicine in St. Louis has launched its new Center for the Study of Itch, believed to be the world’s first multidisciplinary program designed solely to understand and treat itch.

The center was established to bring scientists and clinicians together to conduct research on the mechanisms that transmit itch and, ultimately, to translate those findings into better treatments for chronic sufferers.

Patients with chronic itch include those with certain types of cancer and those with liver and…

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