Chen

Zhou-Feng Chen, PhD

Director, Center for the Study of Itch

Russell D. and Mary B. Shelden Professor of Anesthesiology, Psychiatry and Developmental Biology


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Biography

Dr. Zhou-Feng Chen received his B.S. degree in virology from Wuhan University in 1983 and his Ph.D. Degree in mouse genetics from University of Texas Health Science Center at Houston in 1994, under the supervision of Prof. Richard Behringer.  After completing a postdoctoral training in Prof. David Anderson’s lab at Caltech, he joined the department of Anesthesiology as an assistant professor at Washington University School of Medicine in 2000 and became a full professor in 2009.  His research focuses on understanding of neural circuits of itch and pain with a wide range of interests including neuronal GPCR signaling in itch, descending and modulation and coding logics of itch and pain.  His team identified the first itch-specific receptor Gastrin-releasing peptide receptor (GRPR) and neural circuits in the spinal cord.  These seminal discoveries have opened up an exciting new frontier for deciphering itch circuits and function.  Ongoing research program is centered on signaling and synaptic mechanisms of itch transmission from the skin to the brain and crosstalk between itch and pain. Genetic and molecular tools are being developed to mark and isolate itch neurons for molecular, electrophysiological, cellular and circuit analysis. Detailed elucidation of how GRPR and/or GRPR neurons receive, process and relay itch information may shed insights onto potential therapies for chronic itch.


Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.

Kim S*, Barry DM*, Liu XY*, Yin S, Munanairi A, Meng QT, Cheng W, Mo P, Wan L, Liu SB, Ratnayake K, Zhao ZQ, Gautam N, Zheng J,Karunarathne WK, Chen ZF.Sci Signal. 2016 Jul 19;9(437) PMID: 27436359. (*These authors contributed equally to this work.)

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Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord.

Barry DM, Li H, Liu XY, Shen KF, Liu XT, Wu ZY, Munanairi A, Chen XJ, Yin J, Sun YG, Li YQ, Chen ZF. Mol Pain. 2016 Apr 11;12. pii: 1744806916643724. doi: 10.1177/1744806916643724. Print 2016 Feb.

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Zhou-Feng Chen named Shelden Professor in Anesthesiology

Congratulations! Dr. Zhoufeng Chen named Shelden Professor in Anesthesiology. Please read news here.

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Why itch is contagious?

Dr. Zhou-Feng Chen's team discovers why mice scratch in response to other mice scratching. Read news RecordSt.Louis Public RadioIndependent, NBC, Daily Mail, The Guardian, Hoffington Post, SmithsonianExpress, livescience, Inverse, Cell, 知识分子. Watch video here: Scientific American.

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New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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Research identifies a pair of itchy channels for treating itch

Dr. Zhou-Feng Chen's team has identified a pair of itchy ion channels working in concert to transmit different types of itch in sensory neurons, providing potential new targets for treating itch. For details, please read the news.

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Why scratching makes you itch more?

Read the story in The Record. Watch the video abstract here.

Also in the News:
NBC Nightly News (video)Inside science (video)D News (video)NZ 3 News (video)ScoopStop (video)AAAS (podcast)BBCHuffington PostThe TelegraphThe Washington PostThe Daily MailNew ScientistThe IndependentScience News, Mirror, IFL Science, Fox NewsDermatology TimesPsychology Today.

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