Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

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Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


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CSI News

Welcome Dr. Brian Kim, a new faculty, to join the CSI

We’re excited to announce that Brian Kim is joining CSI as an assistant professor and a physician scientist, starting from July 1, 2014. Dr. Brian Kim received his B.S. in Chemistry from Haverford College in 2001 and his M.D. from the University of Washington School of Medicine in 2007. He trained under Dr. Stephen Katz in the National Cancer Institute from 2004-2006. In 2008, he entered his residency in dermatology at the Perelman School of Medicine at the University of…

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Welcome Dr. Hongzhen Hu, a new faculty, to join the CSI

We would like to welcome Dr. Hongzhen Hu to join CSI as an assistant professor, starting on June 1, 2014.  Dr. Hu received his Ph.D. at the Ohio State University and conducted his post-doctoral training under Dr. Ardem Patapoutian at the Genomics Institute of the Novartis Research Foundation and the Scripps Research Institute. Prior to joining CSI, he was an assistant professor at the department of integrative biology and pharmacology at the University of Texas Health Science Center at Houston. 

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New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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Recent Publications

Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development.

Oh, I.Y., Albea, D.M., Goodwin, Z.A., Quiggle, A.M., Baker, B.P., Guggisberg, A.M., Kroner, G.M., de Guzman Strong, C. (2014) Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development. (J Invest Dermatol., epub ahead of print). PMID: 24468747.

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B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway

Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ and Chen ZF. Mol Pain. 2014; 10:4

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Chronic itch development in sensory neurons requires BRAF signaling pathways

Zhao ZQ*, Huo FQ*, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey, JF Jr., Zhong J and Chen ZF. (*equal contribution) . J Clin Invest. 2013; 123(11):4769–4780

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