Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 

Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


 See All News

CSI News

Brian Kim named the recipient of 2016 Clinical Scientist Development Award by DDCF, Congratulations!

Dr. Brian Kim won the prestigious 2016 Clinical Scientist Development Award, according to The Doris Duke Charitable Foundation's announcement.  He is one of the 17 exceptional physician scientists selected from 169 applicants by a panel of experts in medical experts. Congratulations to Dr. Brian Kim!  Please read DDCF award announcement here.

Read More 

Research identifies a pair of itchy channels for treating itch

Dr. Zhou-Feng Chen's team has identified a pair of itchy ion channels working in concert to transmit different types of itch in sensory neurons, providing potential new targets for treating itch. For details, please read the news.

Read More 

Itching for no reason? Immune system may be at fault

In a small study of patients who have chronic itching with no known cause, researchers from Dr. Brian Kim's lab at the Center for the Study of Itch identified immune system irregularities that may prompt the urge to scratch.

Read the news here. Watch FOX2now TV news here.

Read More 

Qin Liu named a 2015 Pew Scholar, Congratulations!

Qin Liu is among 22 outstanding young scientists named the 2015 class of Pew Scholar in the Biomedical Sciences by the Pew Charitable Trusts. Congratulations to Qin Liu for her achievement ! 

Read the news at the Pew Biomedical Scholars.

Read More 

New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

Read More 

 See All Publications

Recent Publications

Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.

Kim S*, Barry DM*, Liu XY*, Yin S, Munanairi A, Meng QT, Cheng W, Mo P, Wan L, Liu SB, Ratnayake K, Zhao ZQ, Gautam N, Zheng J,Karunarathne WK, Chen ZF.Sci Signal. 2016 Jul 19;9(437) PMID: 27436359. (*These authors contributed equally to this work.)

See details 

Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons.

Gu QD, Moss CR 2nd, Kettelhut KL, Gilbert CA, Hu H. Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Front Physiol. 2016 Feb 29;7:65. PMID: 26973533

See details 

Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.

Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18. PMID: 26756551

See details 

New insights into basophil heterogeneity.

Oetjen LK, Noti M, Kim BS. New insights into basophil heterogeneity. Semin Immunopathol. 2016 May 13. [Epub ahead of print] PMID: 27178409

See details 

Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus.

Xu AZ, Tripathi SV, Kau AL, Schaffer A, Kim BS. Immune dysregulation underlies a subset of patients with chronic idiopathic pruritus. J Am Acad Dermatol. 2016 May;74(5):1017-20. PMID: 27085236

See details 

Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord.


Barry DM, Li H, Liu XY, Shen KF, Liu XT, Wu ZY, Munanairi A, Chen XJ, Yin J, Sun YG, Li YQ, Chen ZFMol Pain. 2016 Apr 11;12. pii: 1744806916643724. doi: 10.1177/1744806916643724. Print 2016 Feb.

See details 

A histamine-independent itch pathway is required for allergic ocular itch.

Huang CC, Kim YS, Olson WP, Li F, Guo C, Luo W, Huang AJ, Liu Q. A histamine-independent itch pathway is required for allergic ocular itch. J Allergy Clin Immunol. 2015 Oct 28. pii: S0091-6749(15)01343-3. doi: 10.1016/j.jaci.2015.08.047. [Epub ahead of print] PubMed PMID: 26521042.

See details