Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

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Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


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CSI News

Amy Xu selected as Howard Hughes fellow to study itch

Third-year medical student and fellowship recipient Amy Xu will spend the year investigating molecular pathways that regulate eczema-associated itch. Her research mentor is former Howard Hughes fellow Brian Kim, MD, assistant professor of medicine.

Kim, who is co-director of the School of Medicine’s Center for the Study of Itch, said the fellowship had a profound influence on his medical career.

“As a medical student, I initially had not intended to go into research, and I was just trying it out,” Kim said of his own…

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Qin Liu named a 2015 Pew Scholar, Congratulations!

Qin Liu is among 22 outstanding young scientists named the 2015 class of Pew Scholar in the Biomedical Sciences by the Pew Charitable Trusts. Congratulations to Qin Liu for her achievement ! 

Read the news at the Pew Biomedical Scholars.

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Why scratching makes you itch more?

Read the story in The Record. Watch the video abstract here.

Also in the News:
NBC Nightly News (video)D News (video)NZ 3 News (video)ScoopStop (video)AAAS (podcast)BBCHuffington PostThe TelegraphThe Washington PostThe Daily MailNew ScientistThe IndependentScience News, Mirror, IFL Science, Fox NewsDermatology TimesPsychology Today

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Welcome Dr. Hongzhen Hu, a new faculty, to join the CSI

We would like to welcome Dr. Hongzhen Hu to join CSI as an assistant professor, starting on June 1, 2014.  Dr. Hu received his Ph.D. at the Ohio State University and conducted his post-doctoral training under Dr. Ardem Patapoutian at the Genomics Institute of the Novartis Research Foundation and the Scripps Research Institute. Prior to joining CSI, he was an assistant professor at the department of integrative biology and pharmacology at the University of Texas Health Science Center at Houston. 

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New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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Recent Publications

Molecular and cellular mechanisms that initiate pain and itch.

Luo J, Feng J, Liu S, Walters ET, Hu H (2015). Molecular and cellular mechanisms that initiates pain and itch. Cell and Mol Life Sci [Epub ahead of print]. PMID: 25894692

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Low Filaggrin Monomer Repeats in African American Pediatric Patients With Moderate to Severe Atopic Dermatitis.

Quiggle AM, Goodwin ZA, Marfatia TR, Kumar MG, Ciliberto H, Bayliss SJ, de Guzman Strong C. (2015) Low filaggrin monomer repeats in African-American pediatric patients with moderate to severe atopic dermatitis. JAMA Dermatology, 2015; 151(5):557-9. PMID:25564772

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Innate Lymphoid Cells in the Skin.

Kim BS. Innate Lymphoid Cells in the Skin. J Invest Dermatol. 2015; 135(3):673-678.

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Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling.

Zhao ZQ, Liu XY, Jeffry J, Karunarathne WKA, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L, Wu ZY, Kim S, Huo FQ, Mo P, Barry DM, Zhang CK, Kim JY, Gautam N, Renner KJ, Li YQ, Chen ZF. Neuron. 2014; 84(4): 821-834.

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Cross-Inhibition of NMBR and GRPR Signaling Maintains Normal Histaminergic Itch Transmission.

Zhao ZQ, Wan L, Liu XY, Huo FQ, Li H, Barry DM, Krieger S, Kim S, Liu ZC, Xu J, Rogers BE, Li YQ, Chen ZF. J Neurosci. 2014 Sep 10;34(37):12402-14. 

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Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development.

Oh, I.Y., Albea, D.M., Goodwin, Z.A., Quiggle, A.M., Baker, B.P., Guggisberg, A.M., Kroner, G.M., de Guzman Strong, C. (2014) Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development. J Invest Dermatol. 134(9):2371-80. PMID: 24468747.

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B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway

Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ and Chen ZF. Mol Pain. 2014; 10:4

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