Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

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Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


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CSI News

Zhou-Feng Chen named Shelden Professor in Anesthesiology

Congratulations! Dr. Zhoufeng Chen named Shelden Professor in Anesthesiology. Please read news here.

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Potential new therapy relieves chronic itch

Congratulations to Dr. Brian Kim's team!

Dr. Brian Kim, dermatologist, and Landon Oetjen, MD/PhD student, of the CSI discover highly promising new pathway for the treatment of chronic itch. Please read news Record, Daily Mail.

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Why itch is contagious?

Dr. Zhou-Feng Chen's team discovers why mice scratch in response to other mice scratching. Read news RecordSt.Louis Public RadioIndependent, NBC, Daily Mail, The Guardian, Hoffington Post, SmithsonianExpress, livescience, Inverse, Cell, 知识分子. Watch video here: Scientific American.

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Brian Kim named the recipient of 2016 Clinical Scientist Development Award by DDCF, Congratulations!

Dr. Brian Kim won the prestigious 2016 Clinical Scientist Development Award, according to The Doris Duke Charitable Foundation's announcement.  He is one of the 17 exceptional physician scientists selected from 169 applicants by a panel of experts in medical experts. Congratulations to Dr. Brian Kim!  Please read DDCF award announcement here.

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New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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Recent Publications

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BSCell. 2017 Sep 21;171(1):217-228.e13. doi: 10.1016/j.cell.2017.08.006. Epub 2017 Sep 7. PMID: 28890086

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Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.

Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.  J Allergy Clin Immunol. 2017  Aug 5. pii: S0091-6749(17)31098-9. doi: 10.1016/j.jaci.2017.05.051. [Epub ahead of print]. PMID:28807414

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The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice.

Feng J, Luo J, Mack MR, Yang P, Zhang F, Wang G, Gong X, Cai T, Mei Z, Kim BS, Yin S, Hu H. The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice. J Allergy Clin Immunol. 2017 Apr 23; pii: S0091-6749(17)30663-2. doi: 10.1016/j.jaci.2017.03.035. [Epub ahead of print]. PMID: 28442325.

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Spinal Mechanisms of Itch Transmission

Barry DM, Munanairi A, Chen ZFNeurosci Bull. 2017 Apr 1. doi: 10.1007/s12264-017-0125-2. [Epub ahead of print] PMID: 28365862.

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Molecular and neural basis of contagious itch behavior in mice.

Yu YQ*, Barry DM*, Hao Y*, Liu XT, Chen ZF. Molecular and neural basis of contagious itch behavior in mice. Science. 2017 Mar 10;355(6329):1072-1076. PMID: 28280205. (*These authors contributed equally to this work.)

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Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.

Goodwin ZA, de Guzman Strong C. (2017) Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.Front Genet. 2017 Jan 10;7:227. PMID: 28119736

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Effect of Counting Genetic Variants on Precision Treatment for Pediatric Atopic Dermatitis: Do Count Your Chickens Before They Hatch.

Mathyer ME, Coughlin CC, de Guzman Strong C. (2016) Effect of Counting Genetic Variants on Precision Treatment for Pediatric Atopic Dermatitis: Do Count Your Chickens Before They Hatch. JAMA Dermatol. 2016 Nov 30. doi: 10.1001/jamadermatol.2016.4468. [Epub ahead of print].PMID: 27902823

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