Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 

Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


 See All News

CSI News

CBS news: Finding new ways to combat chronic itch

Watch here

Read More 

Zhou-Feng Chen named Shelden Professor in Anesthesiology

Congratulations! Dr. Zhoufeng Chen named Shelden Professor in Anesthesiology. Please read news here.

Read More 

Potential new therapy relieves chronic itch

Congratulations to Dr. Brian Kim's team!

Dr. Brian Kim, dermatologist, and Landon Oetjen, MD/PhD student, of the CSI discover highly promising new pathway for the treatment of chronic itch. Please read news Record, Daily Mail.

Read More 

Why itch is contagious?

Dr. Zhou-Feng Chen's team discovers why mice scratch in response to other mice scratching. Read news RecordSt.Louis Public RadioIndependent, NBC, Daily Mail, The Guardian, Hoffington Post, SmithsonianExpress, livescience, Inverse, Cell, 知识分子. Watch video here: Scientific American.

Read More 

New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

Read More 

 See All Publications

Recent Publications

Distinct roles of NMB and GRP in itch transmission.

Wan L, Jin H, Liu XY, Jeffry J, Barry DM, Shen KF, Peng JH, Liu XT, Jin JH, Sun Y, Kim R, Meng QT, Mo P, Yin J, Tao A, Bardoni R, Chen ZF. Distinct roles of NMB and GRP in itch transmission. Sci Rep. 2017 Nov 13;7(1):15466. PMID: 29133874

See details 

Sensory TRP channels contribute differentially to skin inflammation and persistent itch.

Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017 Oct 30;8(1):980. PMID: 29081531. PMCID: PMC5661746. 

See details 

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BSCell. 2017 Sep 21;171(1):217-228.e13. doi: 10.1016/j.cell.2017.08.006. Epub 2017 Sep 7. PMID: 28890086

See details 

Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.

Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.  J Allergy Clin Immunol. 2017  Aug 5. pii: S0091-6749(17)31098-9. doi: 10.1016/j.jaci.2017.05.051. [Epub ahead of print]. PMID:28807414

See details 

The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice.

Feng J, Luo J, Mack MR, Yang P, Zhang F, Wang G, Gong X, Cai T, Mei Z, Kim BS, Yin S, Hu H. The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice. J Allergy Clin Immunol. 2017 Apr 23; pii: S0091-6749(17)30663-2. doi: 10.1016/j.jaci.2017.03.035. [Epub ahead of print]. PMID: 28442325.

See details 

Spinal Mechanisms of Itch Transmission

Barry DM, Munanairi A, Chen ZFNeurosci Bull. 2017 Apr 1. doi: 10.1007/s12264-017-0125-2. [Epub ahead of print] PMID: 28365862.

See details 

Molecular and neural basis of contagious itch behavior in mice.

Yu YQ*, Barry DM*, Hao Y*, Liu XT, Chen ZF. Molecular and neural basis of contagious itch behavior in mice. Science. 2017 Mar 10;355(6329):1072-1076. PMID: 28280205. (*These authors contributed equally to this work.)

See details