Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

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Center for the Study of Itch

The Center for the Study of Itch seeks to understand the fundamental underlying mechanisms of itch and translate these findings into treatments for patients suffering from intractable itch.

Learn more 


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CSI News

New York Times Features Innovative Research at CSI

In a recent interview with The New York Times, Drs. Zhou-Feng Chen and Lynn Cornelius, talk about chronic itch as an unmet need and the clinical implication of the discovery of an itch-specific receptor called GRPR.

Read The New York Time article "Itching: more than deep-skin".

 

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A new study questions the existence of the BNP-NPRA-GRP-GRPR dedicated neuronal pathway for itch

A new study from Dr. Zhou-Feng Chen's laboratory shows that the BNP-NPRA signaling does not function upstream of the GRP-GRPR pathway. A NIH team recently proposed that B-type natriuretic peptide (BNP) but not GRP functions in pruriceptors, and BNP-NPRA acts upstream of the GRP-GRPR signaling pathway dedicated to itch (Reports, Science, May 24, 2013).  Chen's team provides comprehensive evidence supporting the notion that GRP is indeed an itch-specific peptide in pruriceptors. By contrast, BNP protein appears to be expressed in…

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Scientists unravel mechanisms in chronic itching

Anyone who has suffered through sleepless nights due to uncontrollable itching knows that not all itching is the same. New research at Washington University School of Medicine in St. Louis explains why.

Working in mice, the scientists have shown that chronic itching, which can occur in many medical conditions, from eczema and psoriasis to kidney failure and liver disease, is different from the fleeting urge to scratch a mosquito bite.

(Watch Youtube Video for this news)

That’s because chronic…

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Recent Publications

Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development.

Oh, I.Y., Albea, D.M., Goodwin, Z.A., Quiggle, A.M., Baker, B.P., Guggisberg, A.M., Kroner, G.M., de Guzman Strong, C. (2014) Regulation of the dynamic chromatin architecture of the Epidermal Differentiation Complex is mediated by a c-Jun/AP-1-modulated enhancer during skin development. (J Invest Dermatol., epub ahead of print). PMID: 24468747.

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B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway

Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ and Chen ZF. Mol Pain. 2014; 10:4

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Chronic itch development in sensory neurons requires BRAF signaling pathways

Zhao ZQ*, Huo FQ*, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey, JF Jr., Zhong J and Chen ZF. (*equal contribution) . J Clin Invest. 2013; 123(11):4769–4780

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